Renal function and cortical blood flow during the recovery phase of acute renal failure

Renal function and cortical blood flow during the recovery phase of acute renal failure. The characteristics of the recovery process in dichromate-induced acute renal failure were determined. Rats were studied 1, 4, 7, and 14 days after the s.c. injection of either saline or potassium dichromate. In the sham-injected control animals, all values at each interval were similar. The typical pattern of acute renal failure was seen one day after dichromate injection: glomerular filtration rate (GFR) fell 80%, total renal blood flow (TRBF) was reduced 35%, the proportional flow to the outer cortex was diminished, and the urinary to plasma (U/P) inulin clearance was reduced. The early recovery phase, days 4 and 7, was characterized by: 1) a mild but significant diuresis, 2) progressive improvement in GFR and an increase in the proportional flow to the outer cortex, which actually exceeded control values, 3) a dissociation between improvement in renal function and changes in TRBF, since GFR increased progressively while TRBF remained relatively fixed, and 4) improvement in GFR that was associated with a progressive and parallel increase in absolute perfusion of the outer cortex. The present data suggest that the recovery process occurs in two stages. In the first stage, the restoration of outer cortical perfusion and renal function precedes the recovery of TRBF and tubular function, which occur during the second stage of the recovery process.Fonction rénale et débit sanguin rénal cortical au cours de la période de récupération de l'insuffisance rénale aiguë. Les caractéristiques du processus de récupération après une insuffisance rénale aiguë induite par le dichromate, ont été déterminées. Des rats ont été étudiés 1, 4, 7, et l4 jours après l'injection s.c. de dichromate de potassium ou de soluté salé. Chez les animaux contrôles, toutes les valeurs obtenues sont semblables. L'aspect typique de l'insuffisance rénale aiguë est observée un jour après l'injection de dichromate: GFR diminue de 80%, le débit sanquin rénal (TRBF) est réduit de 35%, la fraction de ce débit délivrée au cortex superficiel diminue et le U/P de l'inuline est abaissé. La phase de récupération précoce, aux jours 4 et 7, est caractérisée par: 1) une diurèse peu importante mais significativement plus grande, 2) une amélioration progressive de GFR et une augmentation de la fraction du débit délivrée au cortex superficiel, qui devient supérieure aux valeurs contrôles, 3) une dissociation entre l'amélioration de la fonction rénale indiquée par l'augmentation progressive de GFR, et TRBF qui reste relativement bas, 4) et une amélioration de GFR qui est associée à une augmentation progressive et parallèle du débit absolu de perfusion du cortex superficiel. Ces résultats suggèrent que le processus de récuparation survient en deux étapes. A la première étape, la récupération du débit cortical superficiel et de la fonction rénale précède la récupération de TRBF et de la fonction tubulaire qui constitue la deuxième étape

Decoupling of net community and export production on submesoscales in the Sargasso Sea

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Global Biogeochemical Cycles 29 (2015): 1266–1282, doi:10.1002/2014GB004913.Determinations of the net community production (NCP) in the upper ocean and the particle export production (EP) should balance over long time and large spatial scales. However, recent modeling studies suggest that a horizontal decoupling of flux-regulating processes on submesoscales (≤10 km) could lead to imbalances between individual determinations of NCP and EP. Here we sampled mixed-layer biogeochemical parameters and proxies for NCP and EP during 10, high-spatial resolution (~2 km) surface transects across strong physical gradients in the Sargasso Sea. We observed strong biogeochemical and carbon flux variability in nearly all transects. Spatial coherence among measured biogeochemical parameters within transects was common but rarely did the same parameters covary consistently across transects. Spatial variability was greater in parameters associated with higher trophic levels, such as chlorophyll in >5.0 µm particles, and variability in EP exceeded that of NCP in nearly all cases. Within sampling transects, coincident EP and NCP determinations were uncorrelated. However, when averaged over each transect (30 to 40 km in length), we found NCP and EP to be significantly and positively correlated (R = 0.72, p = 0.04). Transect-averaged EP determinations were slightly smaller than similar NCP values (Type-II regression slope of 0.93, standard deviation = 0.32) but not significantly different from a 1:1 relationship. The results show the importance of appropriate sampling scales when deriving carbon flux budgets from upper ocean observations.NASA Ocean Carbon and Biogeochemistry program Grant Number: NNX11AL94G; WHOI Postdoctoral Scholar fellowship; NASA ACE Grant Number: NNX12AJ25G; NSF Grant Number: OCE-07523662016-02-2

Kinetics and thermodynamics of carbon segregation and graphene growth on Ru(0001)

We measure the concentration of carbon adatoms on the Ru(0001) surface that are in equilibrium with C atoms in the crystal's bulk by monitoring the electron reflectivity of the surface while imaging. During cooling from high temperature, C atoms segregate to the Ru surface, causing graphene islands to nucleate. Using low-energy electron microscopy (LEEM), we measure the growth rate of individual graphene islands and, simultaneously, the local concentration of C adatoms on the surface. We find that graphene growth is fed by the supersaturated, two-dimensional gas of C adatoms rather than by direct exchange between the bulk C and the graphene. At long times, the rate at which C diffuses from the bulk to the surface controls the graphene growth rate. The competition among C in three states - dissolved in Ru, as an adatom, and in graphene - is quantified and discussed. The adatom segregation enthalpy determined by applying the simple Langmuir-McLean model to the temperature-dependent equilibrium concentration seriously disagrees with the value calculated from first-principles. This discrepancy suggests that the assumption in the model of non-interacting C is not valid

The Structure of Episodic Memory: Ganeri's ‘Mental Time Travel and Attention’

We offer a framework for assessing what the structure of episodic memory might be, if one accepts the Buddhist denial of persisting selves. This paper is a response to Jonardon Ganeri's paper "Mental time travel and attention", which explores Buddhaghosa's ideas about memory. (It will eventually be published with a reply by Ganeri)

Leukocytes are primed in peripheral blood for activation during term and preterm labour†

We hypothesized that the priming and activation of maternal leukocytes in peripheral blood is a key component of parturition, and that inappropriate preterm priming of leukocytes might initiate preterm labour and delivery. The purpose of this study was to characterize peripheral blood leukocyte activation during human term and preterm labour. We obtained blood samples from pregnant women at term and preterm, both in labour and not in labour. Leukocytes were characterized according to cell subtype and cell surface marker expression. Additionally, we quantified leukocyte cytokine mRNA production, migratory ability and reactive oxygen species production of neutrophils and macrophages. We found that both term and preterm labour were associated with an increase in monocyte and neutrophil proportion or number—neutrophil migratory ability and cell surface marker expression indicating activation. Messenger RNA expression of IL-1β and IL-8, MCP-1 and TLR-2 was also increased. We conclude that leukocytes in peripheral blood are primed in preparation for activation during term and preterm labour, and that this may contribute to the pathophysiological events of parturition. These data may lead to novel therapies and diagnostic tools for the prevention and/or diagnosis of preterm birth